Synthesis and In-Vivo Analgesic Activity of 1, 2, 4-Thiadiazole Derivatives
نویسنده
چکیده
A new series of Mannich bases MK8-12 has been synthesized from 1, 2, 4thiadiazole by Mannich reaction. All the synthesized compounds of the series displayed, remarkable analgesic activity in comparison to standard drug diclofenac sodium. In the synthesized thiadiazole derivatives MK-8 & MK-10 showed activity at 20mg/kg . MK-9 & MK-11 are considered as most active compounds as they protected 60.85% & 59.55% respectively of animals at a dose of 20mg/kg. Chemical structures of all the new compounds were established by IR, NMR, MS spectroscopy and elemental analysis. Most of these new compounds showed appreciable activity against the test, and emerged as potential molecules for further development.
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